

With equal (ie unlimited) access to both Ketamine is going to be a lot faster. They will both cause psychosis eventually, and both cause irreversible harm to major organs (kidneys/bladder and pancreas) after sustained use, but alcohol takes between 10-20 years of solid abuse before it starts to do serious damage, Ketamine only takes months to a few years.
12 is how you slice through a major tendon in the palm and permanently impair the use of your fingers. Nana needs to be shown how to use a knife.