Reports are inconclusive at the moment. Some users have reported worse performance, others swear that uninstalling mods and/or verifying the game’s files has fixed their performance issues.
This is not the first Capcom game to use Enigma.
EDIT March 3rd, 2026: a bit less than a month after adding it, Capcom has removed DRM from the game. https://steamdb.info/app/2050650/history/
Ghost Trick was originally a DS game, so if you don’t care about HD artwork tracking down the DS version is an option.