French researchers have established the first direct causal link between mitochondrial dysfunction and memory loss in neurodegenerative diseases, demonstrating that restoring brain energy production can reverse cognitive symptoms within hours.
The study, published August 11 in Nature Neuroscience by scientists from Inserm and the University of Bordeaux, developed a precision tool called mitoDREADD-Gs that successfully restored memory function in multiple dementia mouse models by directly stimulating mitochondrial energy production.
“This work is the first to establish a cause-and-effect link between mitochondrial dysfunction and symptoms related to neurodegenerative diseases, suggesting that impaired mitochondrial activity could be at the origin of the onset of neuronal degeneration,” said Marsicano.
I mean, this is obvious. As the cells have an energy problem, it had to be related to the powerhouse of the cell. I could have done this myself.
/s
Let me grab some more power
once the CNO drug wore off, mitochondrial activity again declined
We’ll just have to keep them powered up somehow!
Anyone remember the thinking cap from the Hitchhiker’s Guide to the Galaxy movie? Maybe not so crazy… 😛
Indeed. It doesn’t look like they’re fixing decades of mitochondrial degradation and possible genetic errors. They’re just ramping up production of energy.
Still a win.
It’s a step, and many more will be needed but it’s an awesome step
I got the feeling we’ll se some spectacular stuff in the upcoming decade. For humans.
Me too! So tired of american doomerism.
Yes! But since I’m in the US, I’ll have access to none of it.
The idea of SENS is affordable medication (for exay), and even in the USA potentially having people live longer healthier lives might be seen as good for the economy…
Not enough good compared to all the crazy corruption
???
Who powers the powerhouse?
I dunno, but I’ll buy Algernon some flowers if you’d like.
make shure you put them on his grave in the backyard.
something something mouse
Brain evolution has outpaced the power source
The more intelligent you become, the more problems you’ll have.
powerhouse something amirite
